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PhD candidate in gene regulatory mechanisms underpinning cardiovascular diseases
PhD candidate in gene regulatory mechanisms underpinning cardiovascular diseases
Computationally investigating gene regulatory mechanisms in complex disease- Closing date 23-01-2025
- 246
- 36 hours
- Research university
- Research & Education
- Closing date 23-01-2025
- 246
Job description
We are seeking a motivated PhD student to join our lab at Erasmus University Medical Centre in Rotterdam, exploring the gene regulatory mechanisms underpinning cardiovascular diseases. Type 2 diabetes and elevated blood lipid levels are major risk factors for cardiovascular disease. Genome-wide association studies (GWAS) have identified numerous genetic variants linked to such traits, but the biological mechanisms behind these associations remain unclear. We use population genomics, multi-omics datasets and single cell profiling to bridge the gap between genetic discoveries and clinical application.
The PhD project will focus on a data-driven approach to construct novel polygenic scores and gene regulatory networks using data from large cohorts and in-house experiments on patient-specific iPSC-derived pancreatic cells. The candidate will play a key role in shaping the project and contributing to innovative research, with the ultimate goal of advancing personalised treatments.
Work environment
Our newly established lab is part of the department of internal medicine, the largest department of Erasmus University Medical Centre. Collaboration is at the heart of our research, working closely with clinicians, lab core facilities, and data-driven researchers in various departments. The vascular medicine research lab is a lively environment where students, PhD students, postdocs and analysts work together, always ready to assist each other with research questions and challenges.
Qualifications and skills
- Highly motivated candidate who thrives in a collaborative environment.
- Masters degree in (molecular) biology, biomedical sciences, biotechnology, statistics or related field.
- Excellent command of written and spoken English.
- Basic programming skills (R/Python) and motivation to become proficient.
- Experience in cell culture, gene editing, or single cell profiling is a plus.
Before you apply please check our conditions for employment.
Terms of employment
- You will receive a temporary position for 3,5 years.
- The gross monthly salary is € 3.017,- in the 1st year and increases to € 3.824 ,- in the 4th year (scale OIO).
- Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package. Pension insurance with ABP.
- We take care of approximately 2/3 of the monthly contribution.
- Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.
More information
For more information about this position, please contact Dr. Annique Claringbould (assistant professor), a.claringbould@erasmusmc.nl.
If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.
No agencies please.
Application proces
Application proces
Step 1 - Apply
Did we get you excited about this position? Submit your application through the application button. You will receive a confirmation of receipt from our recruiter right away.
Step 2 - Selection
Based on your application, we check to see if there is a fit between us. We will let you know as soon as possible whether you are invited for an interview.
Step 3 - Job interview
You have been invited for an interview, great! In this first meeting we get to know each other and see if You can form an idea of the position, the department and Erasmus MC. If the interview goes well usually a second interview follows.
Step 4 - Offer and terms of employment
It’s a match! Your future manager will discuss your salary and employment with you. You will also receive more information about our other terms of employment.
Step 5 - Getting started
Your first working day has come! We are more than happy to have you. Your new department will give you a warm welcome and provide you with all the information you need. Enjoy your job at Erasmus MC!
