Postdoc clinical and preclinical dosimetry for radionuclide therapy

Job description

Radionuclide therapy is an emerging treatment modality for patients with metastasized cancer. By systemically administering radiolabeled molecules designed to target cancer cells, this therapy offers a unique approach to precision oncology. Dosimetry plays a crucial role in predicting efficacy, minimizing toxicity, and optimizing existing and newly developed radionuclide therapies.

We are seeking a motivated and skilled postdoctoral researcher to join our team, focusing on clinical and preclinical dosimetry for radionuclide therapy. This role involves advanced and fundamental research aimed at improving treatment planning and dose-response understanding, alongside responsibilities for radiation safety protection within the department.

Responsibilities:

• Conduct research on clinical and preclinical dosimetry for radionuclide therapy.
• Optimize treatment planning and analyze dose-effect relationships.
• Collaborate with researchers to develop and implement specific dosimetry models for various experiments; from in-vitro cells, tissue to small animals and in patients.
• Perform Python-based programming and write Gate/Geant4 Monte Carlo scripts for (pre)clinical dosimetry models.
• Develop quantitative SPECT imaging methods for 177Lu, 225Ac and other novel radionuclides on a state-of-the-art CZT system.

Benefits: 


Collaboration within a multidisciplinary team in an international research environment. Great opportunities to develop your own research area and to publish high-impact research articles and present findings at conferences.

Work environment

The Erasmus MC stands for a healthy population and excellence in healthcare. By conducting groundbreaking work, we aim to push boundaries through leading the way in research, education and healthcare. We have a high level of expertise, and work hard to improve and renew the healthcare of today and the public health of tomorrow. We have access to the latest equipment and techniques in a state-of-the-art environment.

The candidate will be positioned with a dual appointment at the department of Radiology and Nuclear Medicine in the research teams of dr. Julie Nonnekens and dr. Mark Konijnenberg. The group of dr. Nonnekens uses a multidisciplinary approach to advance understanding of the underlying cellular mechanisms of radionuclide therapy with the aim to improve current treatment regimens or invent new ones. Research in the group ranges from preclinical, to computational and clinical studies. More information about the research activities of the lab can be found on www.nonnekenslab.com. Dr. Konijnenberg is member of the clinical physics and technology group. Many dosimetry models have been developed at Erasmus MC and increasingly these models form a crucial element in (pre-)clinical research and clinical practice.

The department of Radiology & Nuclear Medicine is dedicated to high quality patient care, education, and research. Concerning research, the department is known for its forefront research and its state-of-the-art facilities. Radionuclide therapy for neuroendocrine tumors was developed in the department and the preclinical research group has successfully developed and tested various other new radiopharmaceuticals or combinatory treatments from bench to bedside.

Qualifications and skills

• You have a PhD in Medical Physics, Radiobiology, or a related field.
• Proficiency in programming and Monte Carlo simulations is essential.
• Experience in dosimetry, nuclear medicine, or radionuclide therapy is an advantage.
• You have strong organization and English communication skills.
• You are a collaborative team-player with independent problem-solving capabilities.

Before you apply please check our conditions for employment.

Terms of employment

• You will receive a temporary position for one year.
• The gross monthly salary amounts a minimum of € 3.493,- and a maximum of € 5.504,- (scale 10).
• Excellent fringe benefits, such as a 13th month that is already paid out in November and a individual travel expense package.
• An International Office which aids you in preparing for you arrival and stay.
• Pension insurance with ABP. We take care of approximately 2/3 of the monthly contribution.
• Special benefits, such as a incompany physiotherapist and bicycle repairer. And there is also a gym where you can work on your fitness after work.

More information

For more information about position, please contact Julie Nonnekens, associate professor radiobiology, via j.nonnekens@erasmusmc.nl. 

No agencies please.